The transfusion service at a tertiary medical center investigates possible transfusion reactions aft

The transfusion service at a tertiary medical center investigates possible transfusion reactions after inquiries are initiated by clinical teams following transfusion. After implementation of an electronic algorithm that reviews the electronic medical record for changes in vital signs during and after transfusion and automatically flags cases for additional review by the clinician and the blood bank, there is a sharp rise in identified reactions classified as TACO. What is the most likely explanation for this increase? A. The algorithm is flagging more patients who do not meet the full criteria for TACO who are erroneously categorized as TACO, resulting in an increased false-positive rate. B. The algorithm is flagging fewer patients experiencing other transfusion reaction types, resulting in a relative increase in TACO reactions identified, but not a true increase. C. The algorithm is flagging more patients who meet criteria for TACO that would be missed by human transfusion auditors, resulting in an increased true positive rate. D. The algorithm is flagging more patients who do meet criteria for TACO but should not be referred for review, resulting in an increased, but clinically meaningless, true-positive rate.

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