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PEGylation plays an important role in the
PEGylation plays an important role in the formulation of nanoparticle-based therapeutics. Which of the following options are true? A. PEG stands for poly(ethylene glycol) and it is a highly hydrophobic polymer. B. After systemic administration nanoparticles can interact with blood components such as apolipoprotein, albumin, fibrinogen, immunoglobulins, opsonins, which tag the nanoparticle for clearance – this is referred to as protein corona. C. While PEGylated formulations have been approved and are used in the clinic, careful evaluation of safety is important, because recent data indicate prevalence of anti-PEG antibodies in humans. D. PEGylation is also termed Opsonization of nanoparticles.
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