This must include a breakdown of kratim’s

This must include a breakdown of kratim’s route of administration and how this impacts the bioavailability of the drug, the lipophilicity of the drug, and how it impacts the efficacy of Kratom. Elaborate on the active and inactive metabolites of kratom as well as what metabolite is eliminated in the kidney as urine and what metabolite or is it the parent drug that will be reabsorbed back into the body to have its effects on the brain by impacting/ bunding to receptors such as dopamine, serotonin, alpha 1 adrenergic etc. Explain how it affects the brain if it blocks dopamine or other neurotransmitter, how is it metabolized by the liver which includes first pass metabolism, cytochrome P450 enzymes in relation to route of administration ( orally, intravenously, etc) how other organs such as G.I tract impact bioavalibility. These are some ideas that u need to be included in the explaination of ADME of Kratom please i would appreciate it. Dont just post an articles break it down on the basis of these idea for me please!!! Image transcription text Explain in detail pharmacokinetics and pharmacodynamic of Kratom that includes the breakdown of ADME (Absorption, Dis… Show more

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