A 41-year-old man suffering from epilepsy had

A 41-year-old man suffering from epilepsy had been receiving carbamazepine, one tablet daily. The drug has a total clearance of 63 L/h and a hepatic clearance of 62 L/h. The man was recently diagnosed with a skin infection due to Mycobacterium marinum, and treatment with rifampin and ethambutol was started. Knowing that rifampin is a potent inducer of microsomal enzymes, which of the following changes most likely occurred to the pharmacokinetics of carbamazepine? A. The hepatic clearance of the drugs decreased. B. The first-pass loss of the drug decreased. C. The renal clearance of the drug decreased. D. The volume of distribution of the drug increased. E. The half-life of the drug decreased. SCIENCE

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