Week 3 Project Use the blank PDF CMS-1500 Form for

Among post-MI patients, arrhythmias were known to be a risk factor for mortality. New drugs proven to suppress arrhythmias. Did they reduce mortality? • CAST screened post-MI patients with low ejection fraction. If they had enough arrhythmias, and a drug & dose were found that suppressed those >80% of the arrhythmias, patient eligible • Consenting patients randomized to active “effective drug & dose” versus placebo. • Patients followed for arrhythmic death, all-cause death, cardiac arrest, angina, quality of life,… After one year, the CAST trial was stopped early because the active arm had significantly higher mortality than the placebo arm (8.3% vs 3.5%), in particular, arrhythmic mortality (5.7% vs 2.2%). What might be the causes related to excess mortality in the treatment group??

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